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Related Experiment Videos

Chromosomal aberrations in occupation-associated progressive systemic sclerosis

R Bernstein, I Prinsloo, S Zwi

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |August 9, 1980
    PubMed
    Summary

    Gold miners with suspected progressive systemic sclerosis (PSS) showed significant chromosomal abnormalities. These genetic changes, including unstable cells and aneuploidy, were similar to those in non-occupationally exposed PSS patients.

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    Area of Science:

    • Occupational Health
    • Genetics
    • Rheumatology

    Background:

    • An occupational link between progressive systemic sclerosis (PSS) and gold mining was identified in 1957.
    • South African gold miners are a population at risk for PSS.

    Purpose of the Study:

    • To investigate chromosomal aberrations in gold miners suspected of having PSS.
    • To compare chromosomal instability in gold miners with and without definite PSS.

    Main Methods:

    • Cytogenetic analysis of chromosomes from 18 gold miners.
    • Assessment of unstable cells (Cu cells), random aneuploidy, and sister chromatid exchanges.
    • Comparison with control subjects.

    Main Results:

    • Definite PSS cases showed a highly significant increase in Cu cells and aneuploidy (P < 0.001).

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  • Patients with PSS features exhibited significant increases in Cu cells (P < 0.05) and aneuploidy (P < 0.001).
  • Increased sister chromatid exchanges were observed in screened patients.

    • Conclusions:

    • Gold miners with PSS exhibit significant chromosomal instability.
    • The observed genetic changes are comparable to those in PSS patients without occupational exposure.
    • This suggests a potential link between gold mining and the genetic alterations seen in PSS.