[Malignant melanoma, leukoderma and vitiligo]

We report about two patients with malignant melanoma, who developed vitiligo at a site distant from the primary melanoma after surgery and during consecutive immunotherapy. In two patients a leucoderma was observed within the area, where metastatic lymphnodes had been excised, as also reported in the literature. These depigmentations may be due to an immunologic defense mechanism, but there is no evidence, if they represent a favourable sign in the course of malignant melanoma.