Successful renal transplantation in a presensitized recipient after multiple blood transfusions

A presensitized uremic patient, initially considered unfit for transplantation, lost his cytotoxic antibodies during prospective multiple transfusion therapy. He subsequently received a graft from his brother, despite a previously positive crossmatch. Hyperacute rejection did not take place. A mild acute rejection episode on the fourth day readily responded to pulse doses of prednisolone. Graft function is excellent at one month. The possible value of intraoperative blood transfusion is discussed.