Human pancreatic polypeptide: studies in fasting and in the growth hormone deficient state

Human pancreatic polypeptide (hPP) was measured in eight normal subjects and six growth hormone deficient dwarfs after insulin-induced hypoglycemia. hPP concentrations increased similarly in both groups with induction of hypoglycemia. In eight normal subjects fasted for 72 hours, no significant elevation of hPP occurred. This is contrary to a previous report indicating such a relationship. Despite the rationale that hPP might play a role in the metabolism of fasting and that its secretion might be altered by growth hormone, no evidence for these relationships could be documented in man.