Subunit influenza vaccine and its testing in clinical immunology

Subunit adsorbed chemical influenza vaccine [ACI] was tested in subcutaneous administration by the needleless and syringe methods. A weak reactogenicity and a high immunogenic activity of the ACI vaccine was demonstrated after a single administration by the needleless and syringe methods [73.0---75.0% of seroconversions with a geometric mean of the titre of 1:91.0---1:169.0 and a relative increase in antibody titre of 8.1---14.9]. Revaccination increased the mentioned indices to 75.0---86.0%, 1:128.0---1:181.0 and 11.3---16.0, respectively. A many-sided comparison of three preparations [ACI vaccine, "Vaxgrip" and "Mutagripe"] permitted to reveal a number of advantages in the Soviet vaccine. However, all the three preparations ensured an expressed protection against influenza virus.