Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cell surface changes in preneoplastic and neoplastic epithelium

B F Trump, B M Heatfield, P C Phelps

Scanning Electron Microscopy

|January 1, 1980

Summary

Cancer cell plasma membranes show significant alterations, impacting cell specialization, communication, and behavior. These changes in cell junctions, antigens, and ion regulation are crucial for understanding tumor invasion and metastasis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A young child with bilateral diaphragmatic palsy after bilateral bidirectional Glenn shunt.

Mymensingh medical journal : MMJ·2014

Same author

Genetic diversity in relation to heterosis and combining ability in spring wheat.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013

Same author

β-adrenergic sweat secretion as a diagnostic test for cystic fibrosis.

American journal of respiratory and critical care medicine·2012

Same author

Gamma glutamyl transpeptidase in safrole-induced, presumptive premalignant mouse hepatocytes.

Carcinogenesis·2012

Same author

Nephrotoxicity in vitro: Role of ion deregulation in signal transduction following injury-Studies utilizing digital imaging fluorescence microscopy.

Toxicology in vitro : an international journal published in association with BIBRA·2010

Same author

Studies of human bronchial epithelium in vitro: Changes of [Ca(2+)](i) in relation to injury, growth and differentiation.

Toxicology in vitro : an international journal published in association with BIBRA·2010

Area of Science:

Oncology
Cell Biology
Biochemistry

Background:

Neoplastic epithelial cells exhibit profound changes in their plasma membranes.
These alterations are critical for understanding cancer's clinical manifestations and progression.

Purpose of the Study:

To review studies on plasma membrane alterations in neoplastic epithelial cells.
To discuss the sequence of cell membrane changes in various cancer models.

Main Methods:

Review of in vivo and in vitro studies on human tumors and animal models.
Focus on alterations in cell junctions, antigenic and enzyme markers, intramembranous components, ion regulation, and cytoskeleton.

Main Results:

Neoplastic plasma membranes are generally less specialized.

Related Experiment Videos

Observed changes include altered cell junctions, loss/gain of antigens (e.g., ABO, CEA), modified enzyme activity, and shifts in ion ratios.

Cytoskeletal defects and Golgi apparatus dysfunction contribute to malignant behavior.

Conclusions:

Plasma membrane specializations are significantly altered in cancer cells.
These alterations influence cell-cell communication, invasion, and metastasis.
Understanding these changes is key to developing targeted cancer therapies.