Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic hormonal testing in Kallman's syndrome

G Holtz, H O Williamson

    Southern Medical Journal
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study reports on a female patient with Kallman syndrome, finding a blunted gonadotropin response to GnRH stimulation, suggesting a hypothalamic defect. Further research is needed to understand impaired GH and TSH responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mediator release assays based on human or murine immunoglobulin E in allergen standardization.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2007
    Same author

    Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic-pituitary-adrenal axis activity: interaction with serotonergic systems.

    Neuropharmacology·2003
    Same author

    Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.

    Human molecular genetics·2001
    Same author

    Adaptation of registration dossiers to the requirements of the Directive 89/342/EEC (so-called "updating").

    Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt fur Sera und Impfstoffe) zu Frankfurt a.M·2001
    Same author

    Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits.

    Neuroscience·1999
    Same author

    Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.

    Nature neuroscience·1999

    Area of Science:

    • Endocrinology
    • Neuroendocrinology
    • Reproductive Medicine

    Background:

    • Kallman syndrome is a genetic disorder characterized by hypogonadotropic hypogonadism and the absence of the sense of smell.
    • Understanding the hypothalamic-pituitary-gonadal axis is crucial for diagnosing and managing endocrine disorders.

    Observation:

    • A female patient with Kallman syndrome underwent dynamic hypothalamic-pituitary testing.
    • Testing confirmed normal nongonadotropic endocrine function.
    • A blunted gonadotropin response to gonadotropin-releasing hormone (GnRH) stimulation was observed.

    Findings:

    • The findings suggest a hypothalamic defect leading to chronic GnRH deficiency, explaining the poor gonadotropic response to GnRH.
    • Variable prolactin (PRL) responses to chlorpromazine stimulation may be due to heterogeneous hypothalamic defects.

    Related Experiment Videos

  • The mechanisms behind impaired growth hormone (GH) and thyroid-stimulating hormone (TSH) responses remain unclear.

    • Implications:

    • This case highlights the complex neuroendocrine dysregulation in Kallman syndrome.
    • Further investigation into the mechanisms of GH and TSH regulation in this condition is warranted.
    • Clarifying these mechanisms could lead to improved diagnostic and therapeutic strategies for patients with Kallman syndrome and related disorders.