Dynamic hormonal testing in Kallman's syndrome

A female patient with Kallman's syndrome is reported; dynamic hypothalamic-pituitary testing confirmed the integrity of nongonadotropic endocrine function and revealed a blunted gonadotropin response to GnRH stimulation. A hypothalamic defect causing chronic GnRH deficiency is thought responsible for the poor gonadotropic response to short-term GnRH stimulation. Heterogeneous hypothalamic defects may be responsible for the variable PRL responses to chlorpromazine stimulation reported in the literature. The mechanisms responsible for impaired GH and TSH responses to provocative testing are unclear.