[Human antitumor immunity according to leukocyte adherence inhibition test data]

A microvariant of the test of leucocytes adherence inhibition, which results were assessed by fluorescence, has revealed antitumor immune reactions to allogenic tumor antigens in gastric cancer (n = 38) and breast cancer (n = 35) in 51.7 and 68.5% of patients respectively. A correlation between the reaction and stage was found only in breast cancer patients. Postive reactions to heterogenous tumor antigen were noted in 17-25% of cases. The reactions to tumor antigens in nontumor lesions of the corresponding localizations were noted in 29.2 and 25%. The data obtained indicated that homogeneity of the antigenic tumor pattern is high enough within the limits of a particular localization irrespective of the degree of morphological tumor differentiation. It seems essential to take into account some possible autoimmune reactions to normal organotypical antigens to interprete the tumor specificity of the reactions under study.