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Related Experiment Videos

Disopyramide (Norpace)-induced hypoglycemia

I J Goldberg, L K Brown, E J Rayfield

    The American Journal of Medicine
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Disopyramide, an antiarrhythmic drug, can cause serious hypoglycemia. A patient experienced recurring low blood sugar after disopyramide treatment, highlighting a potential adverse effect for clinicians to monitor.

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    Area of Science:

    • Clinical Pharmacology
    • Cardiology
    • Endocrinology

    Background:

    • Disopyramide (Norpace) is a unique antiarrhythmic medication.
    • Adverse drug reactions require thorough investigation for patient safety.

    Observation:

    • A patient developed significant hypoglycemia during disopyramide treatment.
    • Hypoglycemia recurred upon readministration of disopyramide.

    Findings:

    • Investigation involved measuring serum insulin, plasma glucagon, and serum alanine levels.
    • These assessments were conducted during disopyramide rechallenge to understand the mechanism.

    Implications:

    • Fasting hypoglycemia is an unusual complication of disopyramide therapy.
  • Clinicians must be aware of this potential adverse effect.