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Clonidine (Dixarit) for menopausal flushing

R F Edington, J P Chagnon, W M Steinberg

    Canadian Medical Association Journal
    |July 5, 1980
    PubMed
    Summary
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    Clonidine significantly reduced menopausal flushing frequency, severity, and duration compared to placebo. This study suggests clonidine is a safe and effective symptomatic treatment for menopausal hot flashes.

    Area of Science:

    • Gynecology
    • Pharmacology

    Background:

    • Menopausal flushing (hot flashes) significantly impacts quality of life.
    • Estrogen therapy carries risks, necessitating alternative treatments.

    Purpose of the Study:

    • To evaluate the efficacy and safety of clonidine for treating menopausal flushing.
    • To compare clonidine's effectiveness against placebo in a randomized controlled trial.

    Main Methods:

    • A multicentre, randomized, placebo-controlled, double-blind crossover study.
    • 66 patients with recent-onset menopausal flushing received clonidine (0.05 mg twice daily) or placebo.
    • Symptom frequency, severity, and duration were assessed.

    Main Results:

    • Clonidine significantly reduced flushing frequency, severity, and duration compared to placebo.

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  • 78% of patients experienced reduced frequency, 89% reduced severity, and 88% reduced duration with clonidine.
  • Side effects were minimal and similar between clonidine and placebo groups.

    • Conclusions:

    • Clonidine is a potentially useful and safe symptomatic treatment for menopausal flushing.
    • It may reduce the need for estrogen therapy and enhance standard menopausal management.
    • Early assessment of clonidine efficacy is recommended for individual patient care.