Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Richter's syndrome]

J Macák, I Krc, P Kopriva

    Ceskoslovenska Patologie
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This case report details Richter's syndrome development in a patient with chronic lymphatic leukemia. The transformation occurred over two years without chemotherapy, confirmed by lymph node histology showing Reed-Sternberg cells.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The surface modification of the silica-coated magnetic nanoparticles and their application in molecular diagnostics of virus infection.

    Scientific reports·2024
    Same author

    [Lung metastases as the first manifestations of occult medullary microcarcinoma].

    Vnitrni lekarstvi·2013
    Same author

    [Primary hepatic neuroendocrine carcinoma].

    Ceskoslovenska patologie·2012
    Same author

    [What is your diagnosis? Metastatic sarcoma with interdigitating dendritic cells in lymph nodes].

    Ceskoslovenska patologie·2011
    Same author

    Coincidence of chronic lymphocytic leukaemia with Merkel cell carcinoma: deletion of the RB1 gene in both tumors.

    Ceskoslovenska patologie·2011
    Same author

    [What is your diagnosis? Answer: maxillary sinus ameloblastoma with invasion into the ethmoidal vault and nasal cavity].

    Ceskoslovenska patologie·2011

    Area of Science:

    • Hematology
    • Oncology
    • Pathology

    Background:

    • Richter's syndrome is a rare and aggressive transformation of chronic lymphatic leukemia (CLL) into diffuse large B-cell lymphoma.
    • Understanding the transformation pathway is crucial for diagnosis and treatment.

    Observation:

    • A 77-year-old female patient initially presented with chronic lymphatic leukemia (CLL).
    • Over two years, without cytostatic treatment, the patient's condition progressed.
    • The terminal stage exhibited a significant cytological shift, leading to a clinical diagnosis of Richter's syndrome.

    Findings:

    • Histological examination of necroptic lymph node material revealed lymphogranuloma structures with characteristic Reed-Sternberg cells.
    • The patient also exhibited monoclonal gammopathy of the IgM type, an additional significant finding.

    Related Experiment Videos

    Implications:

    • This case highlights the potential for Richter's syndrome to develop in CLL patients even without prior chemotherapy.
    • The presence of Reed-Sternberg cells and IgM monoclonal gammopathy are key diagnostic indicators.
    • Further research into the mechanisms of Richter's transformation is warranted.