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Antibacterial action of quinolones on Escherichia coli. I. Structure/activity relationship
Zentralblatt Fur Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten Und Parasitologie
|March 1, 1980
Abstract:
Quinolones, a large group of substituted heterocyclic compounds synthesized by ICI (U.K.), showed antibacterial activity both in vivo and in vitro studies. In the present work an attempt was made to evaluate their antibacterial activity in relation to their chemical structure. Active compounds possess carboxylic and nitroside groups. Regarding the pattern of growth inhibition quinolone with carboxylic side group showed a different behaviour than quinolone possessing nitro side group.