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Related Experiment Videos

Substrate-turnover interrelationships in fasting neonatal dogs

R M Kliegman, E L Miettinen, P A Adam

    The American Journal of Physiology
    |October 1, 1980
    PubMed
    Summary

    Neonatal dogs regulate glucose and lactate utilization based on substrate availability. Insulin appears to play a minor role in fasting glucose homeostasis in these young canines.

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    Area of Science:

    • Neonatal physiology
    • Metabolic regulation
    • Canine research

    Background:

    • Understanding substrate-turnover relationships is crucial for neonatal metabolic health.
    • Neonatal dogs exhibit unique metabolic adaptations during early life.
    • Maternal nutrition impacts neonatal metabolic profiles.

    Purpose of the Study:

    • To determine substrate-turnover relationships in unanesthetized neonatal dogs.
    • To investigate the role of glucose and lactate utilization in early canine life.
    • To assess the influence of maternal starvation on neonatal metabolic homeostasis.

    Main Methods:

    • Studied unanesthetized, healthy, fasted neonatal dogs during the first day of life.
    • Compared pups born to starved versus control mothers via cesarean section.
    • Measured blood glucose and lactate concentrations, correlating them with substrate turnover.

    Main Results:

    • Pups from starved mothers showed significantly lower blood glucose concentrations.
    • Blood glucose concentrations correlated with glucose utilization in all pups.
    • Lactate turnover was significantly related to lactate concentration and its incorporation into glucose, particularly in pups from starved mothers at 24 hours.

    Conclusions:

    • Neonatal dogs can regulate glucose and lactate utilization based on substrate availability.
    • Insulin secretion likely plays a limited role in fasting neonatal canine glucose homeostasis.
    • Maternal nutritional status significantly influences neonatal metabolic regulation.

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