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Physostigmine antagonizes ketamine

A Toro-Matos, A M Rendon-Platas, E Avila-Valdez

    Anesthesia and Analgesia
    |October 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

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    Physostigmine salicylate significantly shortened recovery time and reduced ketamine-induced nystagmus and blurred vision in healthy volunteers. However, it also increased the incidence of nausea and vomiting.

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Neuroscience

    Background:

    • Ketamine is an anesthetic agent with known side effects.
    • Physostigmine is a reversible cholinesterase inhibitor.
    • Central anticholinergic syndrome symptoms can manifest after ketamine administration.

    Purpose of the Study:

    • To evaluate the effects of physostigmine salicylate on ketamine aftereffects.
    • To determine if physostigmine can counteract ketamine-induced central anticholinergic syndrome symptoms.

    Main Methods:

    • A randomized, cross-over, double-blind trial was conducted.
    • Seven healthy volunteers received intravenous ketamine followed by physostigmine or placebo.
    • Recovery time and specific symptoms were assessed.

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    Main Results:

    • Physostigmine significantly reduced recovery time compared to placebo.
    • Nystagmus and blurred vision resolved faster with physostigmine.
    • Nausea and vomiting occurred more frequently after physostigmine administration.

    Conclusions:

    • Physostigmine effectively counteracts some ketamine aftereffects, including those resembling central anticholinergic syndrome.
    • The pro-cholinergic effects of physostigmine should be considered due to increased gastrointestinal side effects.