Related Experiment Video
Updated: Aug 21, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
Liver specific autoimmunity and chronic liver disease--an enigmatic relationship
Abstract:
Refinements in techniques for identifying liver specific immune responses have currently aroused considerable interest in the role of such immunity in the pathogenesis of chronic hepatic disorders. Presence of antibodies against liver cell membrane was tested for in 242 samples of serum and in 86 liver biopsies from patients with liver diseases as well as from controls. Indirect immunofluorescence tests on isolated rabbit hepatocytes and on human liver cells from biopsies respectively were carried out. In the serum, antibody was detected in 16 per cent, several of these cases belonging to the category of recovering acute viral hepatitis and some to chronic hepatitis or to other liver disorders. Serum HBsAg status in these antibody carriers vary. Antibodies on liver cell membrane were detected in approximately 25 per cent cases of hepatitis. The distribution among different cases were like in case of serum positivity. The pathogenetic role of these antibodies in initiation or progression of disease appears doubtful. It is possible that presence of these antibodies merely represents an immune response following liver injury and may not be responsible in causing acute or chronic liver disease.
Related Concept Videos
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Cirrhosis I: Introduction
Cirrhosis II: Pathophysiology
Chronic Pancreatitis I: Introduction
Chronic Pancreatitis II: Pathophysiology

