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48-hour cephradine and post-prostatectomy bacteriuria

M Williams, D J Hole, R W Murdoch

British Journal of Urology

|August 1, 1980

Summary

Short-term cephradine significantly reduced bacteriuria after transurethral resection but not open prostatectomy. This antibiotic also decreased post-operative complications, suggesting its use is justified in specific surgical contexts.

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Area of Science:

Urology
Infectious Diseases
Pharmacology

Background:

Post-surgical urinary tract infections are a common complication.
Antibiotic prophylaxis is often used to prevent bacteriuria.
The efficacy of specific antibiotics like cephradine requires evaluation for different surgical procedures.

Purpose of the Study:

To evaluate the effectiveness of intramuscular cephradine in preventing significant bacteriuria.
To assess the impact of cephradine on post-operative complications following transurethral resection and open prostatectomy.

Main Methods:

A randomized, controlled trial was conducted.
Intramuscular cephradine (1 g 6-hourly for 48 hours) was administered.
Patients undergoing transurethral resection and open prostatectomy were studied.

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Main Results:

Significant reduction in bacteriuria incidence observed after transurethral resection.
No significant change in bacteriuria incidence noted after open prostatectomy.
Reduced post-operative complications in patients receiving cephradine.

Conclusions:

Short-term cephradine is effective in preventing bacteriuria after transurethral resection.
Cephradine may not be effective for preventing bacteriuria after open prostatectomy.
The use of short-term cephradine is justified due to reduced complications.