Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent experience with heart transplantation

T A English, D K Cooper, R Cory-Pearce

    British Medical Journal
    |September 13, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Adherence to controller asthma medications: 6-month prevalence across a US community pharmacy chain.

    Journal of clinical pharmacy and therapeutics·2015
    Same author

    PERV Methodology.

    Xenotransplantation·2006
    Same author

    The pig as a source of cardiac xenografts.

    Journal of cardiac surgery·2002
    Same author

    Transplantation of islets of Langerhans: new developments.

    Swiss medical weekly·2002
    Same author

    Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade.

    Transplantation·2002
    Same author

    Assessment of methotrexate as a potential immunosuppressive agent in baboons.

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2001
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Clinical heart transplantation resumed in the UK due to improved outcomes and donor heart preservation. Early results show promising graft function, though immunosuppression and cost remain challenges for heart transplant recipients.

    Area of Science:

    • Cardiology
    • Transplantation Medicine
    • Surgical Innovation

    Background:

    • Clinical heart transplantation recommenced in the UK, influenced by improved outcomes from Stanford University.
    • Clarification in diagnosing brain death and advancements in donor heart preservation were key factors.
    • The study focuses on early outcomes of heart transplantation at Papworth Hospital.

    Purpose of the Study:

    • To evaluate the initial outcomes of heart transplantation in a cohort of male patients.
    • To assess graft function, patient survival, and recovery post-transplant.
    • To identify challenges and potential areas for improvement in heart transplantation protocols.

    Main Methods:

    • Twelve male patients (16-52 years) with cardiomyopathies or ischemic heart disease received transplants.

    Related Experiment Videos

  • Donor hearts were transported using combined road and air methods, with ischemic times ranging from 108-171 minutes.
  • Postoperative management included immunosuppression with equine antihuman thymocyte globulin, prednisolone, and azathioprine, alongside regular endomyocardial biopsies.

    • Main Results:

    • Early graft function was satisfactory in all cases.
    • Three deaths occurred: one from brain damage, two from rejection within 76 days.
    • Six of the nine surviving patients were discharged, and three returned to work.

    Conclusions:

    • Heart transplantation shows potential benefits for many patients, but high costs are a significant barrier.
    • Development of effective, non-toxic immunosuppressive agents could reduce costs.
    • Continued careful evaluation of heart transplantation benefits is essential.