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[Effect of the antifolic preparation, tomizin, that possesses antitumor activity, on thyroid gland function]
Abstract:
Experimental investigations and clinical observations on the use of alkylating antineoplastic agents demonstrated these to influence the thyroid function. It is worthwhile to assess the effect of the antimetabolite tomizine, displaying antineoplastic properties, on the function of this organ. Tests conducted on rats with sarcoma M-1 disclosed the maximally tolerated doses of tomizine to produce a marked inhibition of the thyroid function. The latter is attended by a reduced accumulation of introduced 131I in the iron. Structural changes in the thyroid occurring under the effect of tomizine are characterized by the lowering of the thyroid epithelium height, increased dimensions of the follicles and a diminished volume of the insular tissue. This also points to depression of the thyroid function. Disturbances in this organ taking place under the effect of a single introduction of tomizine may be reversible. Multiple administration of the drug produces persistent functional disorders in the organ.
Insights
Tomizine, an antineoplastic agent, significantly inhibits thyroid function in rats, reducing iodine uptake and altering thyroid structure. While single doses may be reversible, multiple administrations cause persistent thyroid disorders.
Area of Science:
- Oncology
- Endocrinology
- Pharmacology
Background:
- Alkylating antineoplastic agents are known to affect thyroid function.
- The antimetabolite tomizine exhibits antineoplastic properties.
- The impact of tomizine on thyroid function requires investigation.
Purpose of the Study:
- To assess the effect of tomizine on thyroid function.
- To investigate the structural and functional changes in the thyroid gland induced by tomizine.
Main Methods:
- Experiments were conducted on rats bearing sarcoma M-1.
- Maximally tolerated doses of tomizine were administered.
- Thyroid function was assessed by measuring 131I accumulation.
- Thyroid tissue structure was examined for changes.
Main Results:
- Tomizine markedly inhibited thyroid function.
- A reduction in 131I accumulation in the thyroid was observed.
- Structural changes included decreased thyroid epithelium height, enlarged follicles, and diminished insular tissue.
- Single tomizine administration showed potentially reversible effects.
- Multiple administrations led to persistent functional disorders.
Conclusions:
- Tomizine depresses thyroid function and alters its structure.
- The effects of tomizine on the thyroid can be dose-dependent and duration-dependent.
- Further research is needed to understand the long-term implications of tomizine treatment on thyroid health.