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The cell-to-cell channel

W R Loewenstein, Y Kanno, S J Socolar

    Federation Proceedings
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Most organized cells form stable aqueous membrane channels for cell-to-cell communication. These channels, crucial for tissue function, can be regulated by calcium ion levels.

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    Area of Science:

    • Cell biology
    • Biophysics
    • Tissue engineering

    Background:

    • Cells in organized tissues communicate via aqueous membrane channels.
    • These channels form at cell junctions, facilitating intercellular transport.
    • Understanding channel formation and regulation is key to tissue function.

    Purpose of the Study:

    • To investigate the formation and characteristics of cell-to-cell aqueous membrane channels.
    • To explore the role of calcium ions in regulating these channels.
    • To quantify channel conductance during junction development.

    Main Methods:

    • Monitoring cell-to-cell conductance during junction formation.
    • Measuring the diameter of intercellular channels.
    • Observing the effect of elevated cytoplasmic free calcium on channel activity.

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    Main Results:

    • Nascent cell junctions exhibit progressive increases in conductance, indicating channel formation.
    • Intercellular channels were found to be stable structures.
    • Increased cytoplasmic free calcium concentration induced a graded closure of these channels.

    Conclusions:

    • Cell-to-cell channels form dynamically and are stable once established.
    • Calcium ions act as a regulator, capable of modulating channel permeability.
    • These findings provide insights into the biophysical mechanisms of cell communication and tissue organization.