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Urinary zinc excretion during treatment with different diuretics
Acta Medica Scandinavica
|January 1, 1980
Summary
Diuretic medications can increase urinary zinc loss. Thiazide diuretics significantly increased zinc excretion, while loop diuretics had a lesser effect, highlighting the need for further research on zinc balance during diuretic therapy.
Area of Science:
- Nephrology
- Clinical Pharmacology
- Human Metabolism
Background:
- Zinc is an essential mineral crucial for numerous metabolic processes.
- Diuretics are widely prescribed for various medical conditions, including hypertension and edema.
- Potential interactions between diuretics and essential mineral excretion warrant investigation.
Purpose of the Study:
- To investigate the effect of different classes of diuretics on urinary zinc excretion.
- To compare the impact of thiazide diuretics versus loop diuretics on zinc balance.
Main Methods:
- A randomized trial involving 18 patients undergoing diuretic treatment.
- Patients were divided into two groups: one receiving thiazides (bendroflumethiazide, chlorthalidone, hydrochlorothiazide) and the other receiving loop diuretics (bumetanide, furosemide, triamterene).
- Urinary zinc concentration and total excretion were measured during treatment.
Main Results:
- Thiazide diuretic treatment led to a 30% increase in urine zinc concentration and a 60% increase in total zinc excretion.
- Loop diuretic treatment resulted in diminished urine zinc concentration and a less pronounced increase in total zinc excretion compared to thiazides.
- Significant differences in urinary zinc losses were observed between the two diuretic classes.
Conclusions:
- Thiazide diuretics significantly increase urinary zinc losses.
- Loop diuretics have a comparatively smaller impact on urinary zinc excretion.
- The substantial urinary zinc losses induced by diuretics, particularly thiazides, necessitate further attention due to zinc's essential role in metabolism.