Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum ferritin in hematologic malignancies

Y Matzner, A M Konijn, C Hershko

    American Journal of Hematology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neutrophil Function in Hematological Neoplasia.

    Leukemia & lymphoma·2016
    Same author

    Combined clozapine-lithium treatment for schizophrenia and schizoaffective disorder.

    European psychiatry : the journal of the Association of European Psychiatrists·2009
    Same author

    [Conclusions and recommendations of a WHO expert consultation meeting on iron supplementation for infants and young children in malaria endemic areas].

    Medecine tropicale : revue du Corps de sante colonial·2008
    Same author

    Objectives and methods of iron chelation therapy.

    Bioinorganic chemistry and applications·2008
    Same author

    [Lead poisoning by contaminated flour: an unfinished story].

    Harefuah·2005
    Same author

    Macrophages promote development of human erythroid precursors in transferrin-free culture medium.

    Hematology (Amsterdam, Netherlands)·2005
    Same journal

    High Proportion of PNH Type II Neutrophils Is Associated With Thrombosis in Patients Displaying a PNH Clone ≥ 1.

    American journal of hematology·2026
    Same journal

    Peripheral Blood Lymphocytosis Reflecting an Underlying Thymoma.

    American journal of hematology·2026
    Same journal

    Undetectable Hydroxyurea Levels in the Majority of Sickle Cell Disease Patients, Especially in Young Children.

    American journal of hematology·2026
    Same journal

    Myelodysplastic Syndromes: 2026 Update on Diagnosis, Risk-Stratification and Management.

    American journal of hematology·2026
    Same journal

    Signaling Mutations Negate the Favorable Impact of NPM1 Mutations in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With VEN/HMA.

    American journal of hematology·2026
    Same journal

    Comparative Efficacy of Intranasal, Intramuscular, and Intravenous Vitamin B12 Therapy for Hematological Recovery in Vitamin B12 Deficiency Anemia: A Randomized Controlled Trial.

    American journal of hematology·2026
    See all related articles

    Serum ferritin levels are elevated in acute leukemias and lymphomas at diagnosis and relapse. Normalization of serum ferritin indicates remission, suggesting its clinical utility in monitoring hematologic malignancies.

    Area of Science:

    • Hematology
    • Oncology
    • Biochemistry

    Background:

    • Serum ferritin is an iron storage protein.
    • Elevated serum ferritin levels are observed in various inflammatory and malignant conditions.
    • Its role in hematologic malignancies requires further elucidation.

    Purpose of the Study:

    • To investigate the correlation between serum ferritin levels and different hematologic malignancies.
    • To assess the utility of serum ferritin as a biomarker for disease status (presentation, remission, relapse) and treatment response.

    Main Methods:

    • Serum ferritin levels were measured in patients with various hematologic malignancies.
    • Measurements were taken at presentation, during remission after therapy, and at relapse.
    • Data were analyzed in relation to specific diagnoses (acute leukemias, chronic myeloid leukemia, malignant lymphomas) and tumor histology.

    Related Experiment Videos

    Main Results:

    • Strikingly increased serum ferritin was observed in acute leukemias (acute lymphoblastic leukemia - ALL, acute non-lymphoblastic leukemia - ANLL) at presentation and relapse, and in the blastic crisis of chronic myeloid leukemia (CML).
    • Remission in ALL and ANLL was associated with reduced serum ferritin levels, correlating with remission duration.
    • In malignant lymphomas, serum ferritin levels varied with histology: highest in Hodgkin disease and histiocytic lymphoma, normal in lymphocytic lymphoma, and intermediate in mixed histiocytic-lymphocytic lymphoma.
    • Normalization of serum ferritin was consistently observed upon remission across all studied hematologic malignancies.

    Conclusions:

    • Serum ferritin levels are significantly altered in various hematologic malignancies.
    • Serum ferritin serves as a potential biomarker for assessing disease activity and response to therapy in acute leukemia and malignant lymphoma.
    • Further research can explore its prognostic value and integration into clinical management protocols.