Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Analgesics, allergy and asthma

A Szczeklik

    British Journal of Clinical Pharmacology
    |October 1, 1980
    PubMed
    Summary

    Idiosyncratic reactions to analgesics like aspirin can cause asthma by affecting cyclooxygenase and arachidonic acid metabolism. Other reactions, including urticaria and anaphylaxis, have varied causes, some immunological.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Induced sputum supernatant bioactive lipid mediators can identify subtypes of asthma.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2015
    Same author

    Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs.

    Allergy·2013
    Same author

    Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs.

    The Journal of allergy and clinical immunology·2012
    Same author

    12-hydroxy-eicosatetraenoic acid (12-HETE): a biomarker of Churg-Strauss syndrome.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2012
    Same author

    Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The Pilot Study.

    Journal of allergy·2012
    Same author

    Serum tryptase level is a better predictor of systemic side effects than prostaglandin D2 metabolites during venom immunotherapy in children.

    Journal of investigational allergology & clinical immunology·2011

    Area of Science:

    • Pharmacology
    • Immunology
    • Clinical Medicine

    Background:

    • Idiosyncratic reactions to analgesics present diverse clinical patterns and underlying pathogenetic mechanisms.
    • Aspirin-induced asthma is frequently linked to cyclooxygenase inhibition and subsequent arachidonic acid metabolism disturbances.
    • Urticaria/angioedema reactions to analgesics involve cyclooxygenase inhibition, impurities in drug preparations, or unknown mechanisms.

    Purpose of the Study:

    • To elucidate the distinct pathogenetic pathways of idiosyncratic reactions to common analgesics.
    • To differentiate mechanisms underlying aspirin-induced asthma, urticaria/angioedema, and pyrazolone drug hypersensitivity.

    Main Methods:

    • Review of recent clinical studies on analgesic-induced hypersensitivity reactions.
    • Analysis of pathogenetic mechanisms including cyclooxygenase inhibition and immunological responses.
    • Categorization of reactions based on clinical presentation and suspected etiological factors.

    Main Results:

    • Cyclooxygenase inhibition is central to aspirin-induced asthma and some urticaria/angioedema cases.
    • Impurities in aspirin preparations and unknown factors contribute to other urticaria/angioedema instances.
    • A subset of patients exhibits hypersensitivity to pyrazolone drugs, distinct from aspirin reactions, suggesting an immunological basis.

    Conclusions:

    • Idiosyncratic reactions to analgesics are heterogeneous, with varied pathogenetic roots.
    • Understanding these mechanisms is crucial for accurate diagnosis and management of adverse drug reactions.
    • Immunological mechanisms appear significant in specific analgesic hypersensitivity syndromes.

    Related Experiment Videos