[Morphological changes in the transplanted rat kidney under conditions of minor and major histocompatibility...

Morphological changes in transplanted kidney were studied in 4 groups of rats with different histocompatibility differences between donor and recipient: 1. syngenetic differences, 2. differences in the main histocompatibility system H-1, 3. differences in the H-1 as well as in the subsidiary non-H-1 systems, 4. differences in the non-H-1 systems. -- In all the kidneys transplanted from a newly developed congenetic strain BP.1N to inbred rats of the BN strain (with differences in the non-H-1 systems) rejection developed in 2 to 3 weeks with manifestations of giant-cell interstitial nephritis with gradual destruction and phagocytosis of cortical tubules probably due to the production of antibodies against the basal membranes of tubules. -- In the paralel group with differences in the non-H-1 systems of BP into BN-1B, destroyed after 30 days, there were -- in addition to moderate acute rejection -- hypercellular glomerules with electrodense deposits in the mesangium seen as a manifestation of immuno-complex glomerulonephritis. Analogical glomerular changes without rejection were also fond in a control group of longer surviving syngenetic rats.