Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aminothiadiazoles

D L Hill

    Cancer Chemotherapy and Pharmacology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    2-Amino-1,3,4-thiadiazole (ATDA) exhibits antitumor and uricogenic effects, often reversed by nicotinamide. ATDA acts as an IMP dehydrogenase inhibitor, potentially explaining increased uric acid synthesis and its use in cancer clinical trials.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pre-calving lying duration is associated with transition cow health and performance in multiparous dairy cows.

    Journal of dairy science·2026
    Same author

    Assessing transition cow management in dairy cows for improved health, milk production, pregnancy, and culling outcomes.

    Journal of dairy science·2024
    Same author

    Myelination of the developing lateral olfactory tract and anterior commissure.

    The Journal of comparative neurology·2018
    Same author

    Dairy cattle in a temperate climate: the effects of weather on milk yield and composition depend on management.

    Animal : an international journal of animal bioscience·2014
    Same author

    Prevention of excess weight gain in paediatric primary care: beverages only or multiple lifestyle factors. The Smart Step Study, a cluster-randomized clinical trial.

    Pediatric obesity·2014
    Same author

    Resting energy expenditure and adiposity accretion among children with Down syndrome: a 3-year prospective study.

    European journal of clinical nutrition·2013
    Same journal

    Composition and structure of stratum corneum intercellular lipids in patients with osimertinib-induced hand-foot syndrome.

    Cancer chemotherapy and pharmacology·2026
    Same journal

    CDK4/6 inhibitor-statin interaction and rhabdomyolysis in breast cancer treatment: a case-based systematic review.

    Cancer chemotherapy and pharmacology·2026
    Same journal

    ALK rearrangements and resistance mutations in non-small cell lung cancer: molecular mechanisms and therapeutic implications.

    Cancer chemotherapy and pharmacology·2026
    Same journal

    Central nervous system penetration of imatinib in acute lymphoblastic leukemia: Pharmacokinetic analysis and clinical implications.

    Cancer chemotherapy and pharmacology·2026
    Same journal

    Severe Methotrexate toxicity after ectopic pregnancy: a case report managed with continuous renal replacement therapy.

    Cancer chemotherapy and pharmacology·2026
    Same journal

    Model-based meta-analysis of individual patient data for the characterization of intravenous 5-fluorouracil population pharmacokinetics.

    Cancer chemotherapy and pharmacology·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Oncology

    Background:

    • 2-Amino-1,3,4-thiadiazole (ATDA) and its analogs possess antitumor, uricogenic, and teratogenic properties.
    • Nicotinamide generally reverses the biological effects of ATDA.
    • ATDA is minimally metabolized but forms an NAD+ analog that inhibits IMP dehydrogenase.

    Purpose of the Study:

    • To investigate the mechanism behind ATDA's biological activities, particularly its uricogenic effects.
    • To explore the link between IMP dehydrogenase inhibition and uric acid synthesis.
    • To understand the basis for ATDA's moderate antitumor activity and its progression to clinical trials.

    Main Methods:

    • Enzyme inhibition assays to determine ATDA's effect on IMP dehydrogenase.
    • Metabolic studies in animals to identify ATDA metabolites.

    Related Experiment Videos

  • Observation of uric acid synthesis in humans and chick embryos exposed to ATDA.
  • Review of clinical trial data for ATDA's efficacy against experimental tumors.

    • Main Results:

    • ATDA is identified as a potent inhibitor of IMP dehydrogenase.
    • A metabolite of ATDA acts as an NAD+ or nucleotide analog, causing enzyme inhibition.
    • Increased de novo uric acid synthesis is observed in subjects treated with ATDA.
    • ATDA demonstrates moderate activity against experimental tumors, warranting human trials.

    Conclusions:

    • ATDA's IMP dehydrogenase inhibition is the likely mechanism for its uricogenic effects.
    • The antitumor potential of ATDA is moderate but sufficient for clinical investigation.
    • Further research into ATDA analogs may yield more effective therapeutic agents.