Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

566
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
566
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

1.3K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.3K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

879
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
879
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

752
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
752
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

461
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
461
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

800
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
800

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunoassay with cytomegalovirus early antigens from gene products p52 and CM2 (UL44 and UL57) detects active infection in patients with chronic fatigue syndrome.

Journal of clinical pathology·2007
Same author

A small, randomized, placebo-controlled trial of the use of antiviral therapy for patients with chronic fatigue syndrome.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001
Same author

Editorial response: microbial persistence and idiopathic dilated cardiomyopathy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1999
Same author

Role of bacterial infection in exacerbation of multiple sclerosis.

American journal of physical medicine & rehabilitation·1995
Same author

Abnormal left ventricular myocardial dynamics in eleven patients with chronic fatigue syndrome.

Clinical nuclear medicine·1994
Same author

Repetitively negative changing T waves at 24-h electrocardiographic monitors in patients with the chronic fatigue syndrome. Left ventricular dysfunction in a cohort.

Chest·1993

Related Experiment Video

Updated: Jan 7, 2026

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
03:22

Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

Published on: March 1, 2024

800

The gram-negative bacillary pneumonias

A M Lerner

    Disease-A-Month : DM
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Gram-negative bacillary pneumonias (GNBP) are a major cause of death, especially in debilitated individuals. Despite new antibiotics, mortality remains high, emphasizing the need for early diagnosis and treatment of GNBP.

    More Related Videos

    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
    09:17

    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

    Published on: January 2, 2017

    15.1K
    Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
    11:32

    Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

    Published on: February 23, 2014

    15.5K

    Related Experiment Videos

    Last Updated: Jan 7, 2026

    Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE
    03:22

    Author Spotlight: Advancing Pathogen Detection and Disease Assessment in Real-Time Using M-ROSE

    Published on: March 1, 2024

    800
    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
    09:17

    A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

    Published on: January 2, 2017

    15.1K
    Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
    11:32

    Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

    Published on: February 23, 2014

    15.5K

    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Pulmonology

    Background:

    • Oropharyngeal flora colonization with aerobic gram-negative bacilli increases with age, chronic disease, and debility.
    • Gram-negative bacillary pneumonias (GNBP) are a significant cause of mortality, accounting for two-thirds of pneumonia deaths.
    • Despite advances in antibiotics, the case fatality rate for GNBP has shown little improvement over 15 years.

    Purpose of the Study:

    • To review the epidemiology, diagnosis, and treatment of gram-negative bacillary pneumonias (GNBP).
    • To highlight the diagnostic roles of sputum culture, transtracheal aspiration, bronchoscopy, and lung biopsy.
    • To discuss specific GNBP pathogens and factors influencing mortality.

    Main Methods:

    • Review of existing epidemiologic data and clinical literature on GNBP.
    • Discussion of diagnostic techniques including Gram stain, sputum culture, transtracheal aspiration, bronchoscopy, and lung biopsy.
    • Analysis of factors influencing GNBP presentation and outcomes, such as underlying conditions and specific pathogens.

    Main Results:

    • GNBP are increasingly common in debilitated populations and have a high overall mortality rate of approximately 50%.
    • Nosocomial GNBP incidence has decreased due to improved infection control measures related to inhalation therapy devices.
    • Mortality rates vary by pathogen, with Pseudomonas aeruginosa and Escherichia coli infections approaching 70% mortality, while others are around 20%.

    Conclusions:

    • Early recognition and prompt administration of appropriate antibacterial agents are crucial for improving outcomes in GNBP.
    • Specific pathogens like Pseudomonas aeruginosa and Escherichia coli require aggressive treatment due to high mortality.
    • The mortality of certain GNBP is comparable to pneumococcal pneumonia in similar patient populations.