[Pharmacological properties of adicin, Soviet alpha-acetyldigitoxin]

Adicin, Soviet alpha-acetyldigitoxin, obtained from Digitalis lanata Ehrh., c. Scrophulariaceae after isolation from it of celanid is a highly effective cardiotonic of the digitalis type of action. It exerts a favourable ino- and tonotropic and an adverse chronotropic action on the heart. This action is brought up in varied animal species and can be observed for a long time (over 3 hours). Adicin produces no adverse effect on the coronary blood flow and it is conducive to the improvement of venous circulation. The drug does not differ considerably from acedoxin (Hungarian alpha-acetyldigitoxin) from the standpoint of the cardiotonic effect, cumulative properties, elimination rate, biological activity and toxicity. Adicin is recommended for clinical trials with a purpose of replacing imported drugs.