Changes in plasma glucagon after total pancreatectomy in man

Area of Science:

• Endocrinology
• Metabolic Research
• Surgical Science

Background:

• Investigating the role of pancreatic and non-pancreatic glucagon secretion.
• Understanding glucagon's regulation following major pancreatic surgery.

Observation:

• Blood glucagon levels were monitored in two patients undergoing total pancreatectomy.
• Changes in glucagon were assessed before, during, and after the surgical procedure.

Findings:

• A decrease in blood glucagon was observed six hours post-operation.
• Glucagon levels increased without insulin but were suppressed by insulin administration.
• Impaired glucagon secretion response to arginine was noted one and three weeks after surgery.

Implications:

• Highlights the critical role of the pancreas in glucagon regulation.
• Suggests non-pancreatic glucagon sources are insulin-sensitive.
• Provides insights into metabolic alterations after total pancreatectomy.