Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgM associated primary diffuse mesangial proliferative glomerulonephritis

W Lawler, G Williams, P Tarpey

    Journal of Clinical Pathology
    |November 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Why patients choose to purchase a hearing aid privately.

    British journal of audiology·1992
    Same author

    Peripheral insulin administration attenuates the increase in neuropeptide Y concentrations in the hypothalamic arcuate nucleus of fasted rats.

    Peptides·1992
    Same author

    Human insulin.

    Nature·1992
    Same author

    Adult Wilms' tumour: review of 14 patients.

    British journal of urology·1992
    Same author

    Human insulin and hypoglycaemia: burning issue or hot air?

    BMJ (Clinical research ed.)·1992
    Same author

    Sorting out triage.

    Nursing times·1992
    Same journal

    Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

    Journal of clinical pathology·2026
    Same journal

    MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

    Journal of clinical pathology·2026
    Same journal

    Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

    Journal of clinical pathology·2026
    Same journal

    MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

    Journal of clinical pathology·2026
    Same journal

    Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy.

    Journal of clinical pathology·2026
    Same journal

    Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism.

    Journal of clinical pathology·2026
    See all related articles

    IgM associated glomerulonephritis is a distinct kidney disease. This condition often leads to worsening kidney function and hypertension, with a significant risk of end-stage renal failure.

    Area of Science:

    • Nephrology
    • Immunopathology
    • Histopathology

    Background:

    • Immunoglobulin M (IgM) associated glomerulonephritis is a recognized kidney disease.
    • Primary diffuse mesangial proliferative glomerulonephritis characterized by IgM deposition requires further clinicoimmunopathological definition.

    Purpose of the Study:

    • To present a series of IgM associated primary diffuse mesangial proliferative glomerulonephritis cases.
    • To characterize the clinicoimmunopathological features and clinical outcomes of these patients.

    Main Methods:

    • Retrospective analysis of 23 cases with IgM associated glomerulonephritis.
    • Histopathological examination including light and electron microscopy.
    • Clinical data review including presentation and follow-up.

    Related Experiment Videos

    Main Results:

    • All cases showed diffuse mesangial proliferation; 16 had focal global sclerosis, 15 focal segmental sclerosis, and 7 capsular crescents.
    • Electron microscopy revealed electron-dense deposits in 13 cases and mesangial electron density in 18.
    • 14 patients presented with nephrotic syndrome; 10 showed stable renal function, while others experienced deterioration, hypertension, or end-stage renal failure.

    Conclusions:

    • IgM associated mesangial proliferative glomerulonephritis exhibits distinct histopathological and clinical features.
    • The condition is associated with a significant risk of progressive renal dysfunction and end-stage renal failure.
    • It is proposed that IgM associated mesangial proliferative glomerulonephritis be recognized as a distinct clinicoimmunopathological entity.