Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Are histochemical methods for estrogen receptor valid?

G C Chamness, W D Mercer, W L McGuire

    The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer.

    Oncogene·2011
    Same author

    DNA repair signature is associated with anthracycline response in triple negative breast cancer patients.

    Breast cancer research and treatment·2010
    Same author

    Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo.

    Journal of the National Cancer Institute·2000
    Same author

    Prognostic value of p53 for local failure in mastectomy-treated breast cancer patients.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2000
    Same author

    Time-dependence of hazard ratios for prognostic factors in primary breast cancer.

    Breast cancer research and treatment·1999
    Same author

    Mitosin (a new proliferation marker) correlates with clinical outcome in node-negative breast cancer.

    Cancer research·1998
    Same journal

    Expression and Spatial Localization of Glycosaminoglycan Types in Cartilage From Different Anatomical Locations.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    Aquaporin-4 Localization in Terminal Glial Cells of Human Mechanosensory Corpuscles: An Immunohistochemical Study of Penile Tissues.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    Seeing, Interpreting, and Trusting Images in the Age of Artificial Intelligence.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    P63 and Tight Junctions Targeted for Therapy in Human Salivary Duct Adenocarcinoma Cells.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    Human iPSC-Derived Blood Vessel Organoids for Studying Chronic Hypoxia-Induced Microvascular Dysfunction.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    From Manual to Macro: A Reproducible Fiji Workflow for Semi-automated Collagen Fibril Diameter Quantification in Transmission Electron Microscopy.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    See all related articles

    Histochemical methods for detecting estrogen receptors in breast cancer are useful but currently fall short. Further validation is needed to ensure these techniques accurately identify estrogen receptors for patient therapy selection.

    Area of Science:

    • Biochemistry
    • Oncology
    • Histopathology

    Background:

    • Estrogen receptor (ER) status is crucial for selecting breast cancer therapies.
    • Histochemical and immunohistochemical methods aim to visualize bound estrogen in cells and tissues.

    Purpose of the Study:

    • To critically evaluate existing histochemical methods for estrogen receptor detection.
    • To assess the validity of these methods based on known estrogen receptor properties.

    Main Methods:

    • Review and analysis of proposed histochemical and immunohistochemical techniques.
    • Comparison of methods against established criteria for receptor detection.

    Main Results:

    • Several histochemical methods have been proposed for estrogen receptor visualization.

    Related Experiment Videos

  • Current methods face challenges in accurately detecting estrogen receptors.

    • Conclusions:

    • Despite their potential, existing histochemical methods are unlikely to be reliably detecting estrogen receptors.
    • Further refinement and validation are necessary for accurate ER detection in clinical practice.