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[HDL cholesterol: biochemical aspects (author's transl)]

G Assmann, H Schriewer

    Klinische Wochenschrift
    |August 1, 1980
    PubMed
    Summary

    High density lipoproteins (HDL) are complex macromolecules with varying composition and properties. Discoidal precursors, synthesized by the liver and from chylomicrons, play a key role in cholesterol uptake.

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    Functional foods and cardiometabolic diseases* International Task Force for Prevention of Cardiometabolic Diseases.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2014

    Area of Science:

    • Lipid metabolism and lipoprotein research.
    • Biochemistry of macromolecular assemblies.
    • Cardiovascular disease risk factors.

    Context:

    • High density lipoproteins (HDL) are heterogeneous, spherical macromolecules crucial in lipid transport.
    • HDL composition includes apolipoproteins (A-I, A-II, C), phospholipids, cholesterol, and triglycerides.
    • Isolation and quantification of HDL are typically achieved via apolipoprotein B-containing lipoprotein precipitation and cholesterol or apolipoprotein content determination.

    Purpose:

    • To detail the heterogeneous nature of high density lipoproteins (HDL).
    • To describe the isolation and quantification methods for HDL.
    • To explore the origin and function of discoidal HDL precursors.

    Summary:

    • High density lipoproteins (HDL) exhibit significant heterogeneity in size, composition (apolipoproteins, lipids), and physicochemical properties.
    • HDL can be isolated by precipitating apolipoprotein B-lipoproteins and quantified by measuring cholesterol or apolipoprotein content.
    • A substantial fraction of HDL originates from discoidal phospholipid-apolipoprotein bilayers, synthesized by the liver or derived from chylomicrons.

    Impact:

    • Understanding HDL heterogeneity is vital for accurate assessment of cardiovascular risk.
    • Characterizing discoidal HDL precursors sheds light on their role in reverse cholesterol transport.
    • This research contributes to the broader understanding of lipoprotein metabolism and its implications for health.

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