Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Papaverine and hepatotoxicity

M S Pathy, A J Reynolds

    Postgraduate Medical Journal
    |July 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Sustained release papaverine can cause liver problems. Six of 14 patients showed abnormal liver function, with one developing jaundice, highlighting potential hepatotoxicity risks.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Harmonizing influenza primary-care surveillance in the United Kingdom: piloting two methods to assess the timing and intensity of the seasonal epidemic across several general practice-based surveillance schemes.

    Epidemiology and infection·2014
    Same author

    Impacts of adverse childhood experiences on health, mental health, and substance use in early adulthood: a cohort study of an urban, minority sample in the U.S.

    Child abuse & neglect·2013
    Same author

    Increased reports of Mycoplasma pneumoniae from laboratories in Scotland in 2010 and 2011 - impact of the epidemic in infants.

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2012
    Same author

    Insights into structure-activity relationships and CNS therapeutic applications of NR2B selective antagonists.

    Current medicinal chemistry·2010
    Same author

    Nano-scale composition of commercial white powders for development of latent fingerprints on adhesives.

    Science & justice : journal of the Forensic Science Society·2010
    Same author

    Effects of breed, gender, exercise and white-coat effect on markers of endothelial function in dogs.

    Research in veterinary science·2006
    Same journal

    Dapagliflozin-induced anaphylactic shock.

    Postgraduate medical journal·2026
    Same journal

    Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials.

    Postgraduate medical journal·2026
    Same journal

    Two cases of toxic epidermal necrolysis with severe ocular involvement treated with adjunctive tofacitinib.

    Postgraduate medical journal·2026
    Same journal

    Diastolic dysfunction and diabetes: the DIADAD study-a retrospective cohort study from Liverpool.

    Postgraduate medical journal·2026
    Same journal

    Care, cash, and proof: forensic accountability for war-related starvation.

    Postgraduate medical journal·2026
    Same journal

    Response to traumatic injuries in polo players in England.

    Postgraduate medical journal·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Hepatology
    • Clinical Medicine

    Background:

    • Papaverine, a vasodilator, has been utilized in clinical practice for over a century.
    • Sustained-release formulations aim to improve drug delivery and patient compliance.

    Observation:

    • A clinical study observed 14 patients administered a sustained-release papaverine preparation.
    • Abnormal liver function tests were noted in a significant proportion of the patients.

    Findings:

    • Six out of 14 patients (42.8%) exhibited abnormal liver function tests.
    • One patient presented with jaundice, a clinical sign of liver dysfunction.
    • Another patient underwent a liver biopsy revealing abnormal histology.

    Implications:

    Related Experiment Videos

    • This study adds to the limited reports of papaverine-induced liver injury.
    • Hepatotoxicity should be considered as a potential adverse effect of sustained-release papaverine.
    • Further investigation into the mechanisms and incidence of papaverine hepatotoxicity is warranted.