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Zinc changes after renal allotransplantation

E W Reimold

    Southern Medical Journal
    |November 1, 1980
    PubMed
    Summary

    Plasma and urinary zinc levels in kidney transplant patients returned to normal within weeks after surgery. These transient changes, observed in 72 patients, mirrored those after major operations and were not influenced by rejection or infection.

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    Area of Science:

    • Nephrology
    • Transplantation Immunology
    • Clinical Chemistry

    Background:

    • Zinc homeostasis is crucial for immune function and recovery post-transplant.
    • Understanding zinc metabolism changes after renal allotransplantation is important for patient management.

    Purpose of the Study:

    • To investigate plasma zinc concentration and urinary zinc excretion in renal transplant recipients.
    • To determine the duration of zinc level alterations and their potential correlation with clinical factors.

    Main Methods:

    • Plasma zinc and urinary zinc/creatinine ratios were measured in 72 patients immediately post-transplantation and during a 7.5-year follow-up.
    • Data were compared to healthy control subjects.
    • Influence of rejection, infection, and corticosteroid therapy was assessed.

    Main Results:

    • Plasma zinc was reduced in the first three weeks post-transplant, normalizing within seven weeks.
    • Urinary zinc excretion and zinc/creatinine ratio were elevated during the first week post-transplant.
    • Zinc levels remained within the normal range for the remainder of the follow-up period, irrespective of rejection, infection, or steroid use.

    Conclusions:

    • Transient alterations in zinc metabolism occur after renal allotransplantation, similar to other major surgeries.
    • These changes appear to be self-limiting and not significantly impacted by common post-transplant complications or treatments.

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