Diagnostic techniques in multiple sclerosis

Although multiple sclerosis (MS) has been an area of great interest and effort in numerous scientific disciplines, its etiology, pathogenesis and therapy remain mysterious. Perhaps the most significant advances have resulted from the ability to be more precise in establishing the diagnosis of MS. Among the most important of the new diagnostic tools are electrophysiological techniques for examination of the visual and oculomotor systems. Tests such as the visually evoked potential (VEP) can confirm the existence of clinically suspected lesions and document the presence of asymptomatic ones. Various electrophysiological techniques for detection and evaluation of MS, as well as CSF analysis, psychological and neuroradiological procedures, and immunological observations are described. The relationship between optic neuritis and MS is reviewed, as are therapeutic regimens in use and under study.