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Chronic eosinophilic pneumonia

B Fox, W A Seed

    Thorax
    |August 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    This study investigates eosinophilic pneumonia, a lung condition characterized by eosinophil accumulation. Findings suggest eosinophil granules cause tissue damage and fever, with steroids proving effective in treatment.

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    Area of Science:

    • Pulmonology
    • Pathology
    • Immunology

    Background:

    • Eosinophilic pneumonia is a rare lung disease of unknown cause.
    • Characterized by eosinophil infiltration in lung tissue.
    • Presents with respiratory symptoms and radiographic abnormalities.

    Observation:

    • Three cases of eosinophilic pneumonia were studied clinically and pathologically.
    • Patients exhibited cough, dyspnea, malaise, and fever.
    • Blood eosinophilia and bilateral lung shadowing on radiographs were consistent findings.

    Findings:

    • Lung biopsies revealed intra-alveolar and interstitial eosinophilic pneumonia with associated inflammation.
    • Electron microscopy showed degranulating eosinophils and macrophages containing eosinophil granules.

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  • Immunofluorescence detected immunoglobulins (IgM, IgG, IgA) in lung tissue, but not IgE or complement.

    • Implications:

    • Eosinophil granules are implicated as the cause of tissue damage and fever.
    • Steroid therapy demonstrated rapid resolution of fever and radiographic findings.
    • Small airway dysfunction persisted after clinical remission, suggesting potential long-term effects.