Experiences about the application of gelatin-resorcinol-formaldehyde tissue adhesive in experimental ruptured liver...

Ruptured liver injury was produced in dogs. For arresting the bleeding and for the tissue unifying GRF adhesive was used instead of the traditional wound treatment. The experiences obtained during the wound healing were positive. On the 4th week the adhesive was well markedly emerged from the liver surface, but on the 20th postoperative week the adhesive could not be noticed even by microscopy. The necrosis spread over 10-15 cell lines has nearly disappeared by the end of the 15th week. By this time the granulation tissue filling up the wound transformed into native connective tissue.