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Early insulin response in latent gestational diabetes
Acta Medica Scandinavica
|January 1, 1980
Summary
Women with latent gestational diabetes show a reduced early insulin response (EIR) during pregnancy, which normalizes postpartum. This impaired insulin secretion during pregnancy did not predict future diabetes or adverse birth outcomes.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Metabolic Disorders
Background:
- Gestational diabetes mellitus (GDM) affects glucose metabolism during pregnancy.
- Early insulin response (EIR) is a key indicator of pancreatic beta-cell function.
- Latent gestational diabetes (LD) presents with impaired glucose tolerance but normal fasting glucose.
Purpose of the Study:
- To investigate glucose tolerance and EIR in women with LD during late pregnancy and postpartum.
- To compare EIR between women with LD and a reference group.
- To assess the relationship between EIR and glucose tolerance in different reproductive states.
Main Methods:
- Intravenous glucose tolerance tests were performed.
- Glucose-stimulated early insulin response (EIR) was measured.
- Participants included a reference group (R) and women with latent gestational diabetes (LD).
Main Results:
- Women with LD exhibited a lower EIR during pregnancy compared to the reference group.
- EIR normalized in the LD group postpartum.
- The ability to increase EIR during pregnancy was diminished in some LD women, particularly those with persistent abnormal glucose tolerance postpartum.
Conclusions:
- Latent gestational diabetes is characterized by an impaired early insulin response during pregnancy that resolves postpartum.
- The magnitude of postpartum EIR does not predict the capacity for increased insulin secretion during pregnancy.
- LD did not lead to manifest diabetes during pregnancy or adverse neonatal outcomes in this cohort.