Related Experiment Video
Updated: Aug 12, 2026

Dual Electrophysiological Recordings of Synaptically-evoked Astroglial and Neuronal Responses in Acute Hippocampal Slices
Published on: November 26, 2012
Glutamate in hippocampal pathways
Abstract:
The three consecutive main excitatory neurone projections in the hippocampal formation (the perforant path, the mossy fibres and the pyramidal cell axons) all show acidic amino acid uptake in their terminals. This is in accordance with other data pointing to the transmitter function of glutamate and/or aspartate in the perforant path and pyramidal cell axons. In the mossy fibres the role of these amino acids has so far not been determined. The localization of glutamate and aspartate uptake in the excitatory axon systems contrasts with the localization of GABA uptake in the axons of the inhibitory basket cells and other short axon neurones.
Related Concept Videos
Long-term Potentiation
Long-term Potentiation
Hebbian LTP
LTP can occur when presynaptic neurons...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Role of Hippocampus in Memory
Role of Neurotransmitters in Memory
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is critical for...

