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Local urokinase in arterial thromboembolism
Angiology
|October 1, 1980
Summary
Selective intra-arterial urokinase effectively treats arterial thromboembolism with minimal systemic effects. This approach enhances safety and applicability, especially when combined with surgery for atherosclerotic thrombosis.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Thrombolytic Therapy
Background:
- Recent arterial thromboembolism requires effective treatment.
- Intra-arterial urokinase (UK) offers a targeted approach.
- Systemic thrombolytics like streptokinase have limitations.
Observation:
- Selective intra-arterial urokinase achieves partial lysis.
- A specific UK dose (37,500 UCTA/hour) avoids systemic fibrinolysis.
- This method reduces bleeding and embolism risks.
Findings:
- Intra-arterial UK is effective for recent arterial thromboembolism.
- The treatment is applicable to operative patients.
- Combining surgery with UK shows promise for atherosclerotic arterial thrombosis.
Implications:
- This selective approach expands the use of thrombolysis.
- It offers a safer alternative to systemic treatments.
- Further research into combined surgical and UK protocols is warranted.