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Kidney transplantation and tumours
Annals of Clinical Research
|April 1, 1980
Summary
Renal transplantation may be successful in patients with prior tumors. This study found no increased risk of new tumors after kidney transplants, challenging previous reports.
Area of Science:
- Nephrology
- Oncology
- Transplantation Medicine
Background:
- Renal transplantation is a critical treatment for end-stage renal disease.
- The risk of de novo tumors and the outcomes of transplantation in patients with a history of malignancy require further investigation.
Purpose of the Study:
- To evaluate the success of renal transplantation in patients with pre-existing tumors.
- To assess the incidence and outcomes of de novo tumors after renal transplantation.
Main Methods:
- Retrospective analysis of 602 patients undergoing 700 renal transplants between 1964 and 1978.
- Review of patient histories for pre-transplant tumors and post-transplant de novo tumors.
Main Results:
- Eight patients had a history of tumor before transplantation; treatment was completed a mean of 3 years prior.
- Six cases of de novo tumors were diagnosed post-transplantation, with a mean interval of 2 years.
- Patients with pre-transplant tumors had variable outcomes, with some surviving long-term.
- Outcomes for de novo tumors were mixed, with some patients succumbing to vascular accidents or the tumor itself.
Conclusions:
- Renal transplantation can be a successful treatment option for patients with a history of malignancy.
- This study does not support previous findings of an increased risk of de novo tumors following renal transplantation.