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A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
Published on: April 9, 2019
The "milieu interieur"-a model of brain physiology and pathophysiology
Abstract:
The "milieu interieur" or "internal environment" of the brain is determined by the glial cells, the cerebrospinal fluid, the blood-brain barrier, the cerebral blood flow, the central regulation of respiration, and the intracranial pressure. Anaesthetic agents and anoxia-ischaemic insult can disrupt this important but vulnerable neuronal environment. Head injury is used as an example of a common insult to the neuronal environment and the principles of management are discussed, using a model of brain physiology and pathophysiology which can be modified to include other clinical situations.
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