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Captopril and hypertension development in the SHR

J F Giudicelli, J L Freslon, S Glasson

Clinical and Experimental Hypertension

|January 1, 1980

Summary

Daily captopril administration in young spontaneously hypertensive rats (SHRs) effectively prevented genetic hypertension development. This preventive effect on hypertension persisted long after treatment cessation.

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Area of Science:

Cardiovascular Research
Pharmacology
Hypertension Studies

Background:

Spontaneously hypertensive rats (SHRs) are a widely used model for studying genetic hypertension.
Hypertension development in SHRs is characterized by a progressive increase in peripheral resistance.
Early intervention strategies are crucial for managing and potentially preventing hypertension.

Purpose of the Study:

To investigate the long-term effects of early captopril administration on genetic hypertension development in SHRs.
To assess the impact of captopril on hemodynamic parameters and cardiac remodeling in hypertensive rats.
To determine the persistence of captopril's antihypertensive effects after treatment discontinuation.

Main Methods:

Young SHRs were treated daily with captopril (100mg/kg) via gavage from 6 to 20 weeks of age.
Hemodynamic parameters including peripheral resistance, heart rate, and cardiac output were monitored.
Plasma renin concentration and heart weight/body weight ratio were measured post-treatment.

Main Results:

Captopril treatment almost completely inhibited genetic hypertension development in SHRs.
A sustained limitation of peripheral resistance increase was observed during captopril administration.
Plasma renin concentration increased significantly, while heart weight/body weight ratio decreased.
The preventive effect on hypertension persisted for 12 weeks after treatment cessation.

Conclusions:

Early and continuous captopril administration is highly effective in preventing genetic hypertension in SHRs.
Captopril normalizes peripheral resistance and cardiac remodeling without altering heart rate or cardiac output.
The long-lasting antihypertensive effect suggests a potential for sustained cardiovascular benefits.

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