Related Experiment Video
Updated: May 5, 2026

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration
Published on: May 7, 2018
Quantitative ultrastructural studies on parietal cell regeneration in experimental ulcers in rat gastric mucosa
Abstract:
The regeneration of parietal cells was studied in rat gastric mucosa. For this purpose wounds were produced by cauterization of the corpus mucosa in adult male Sprague-Dawley rats. The animals were killed at 30, 60, 90, 130, and 260 days postoperatively, six at each time. Sham-operated rats, killed at 60 and 260 days, served as controls. Stereologic data were obtained by electron microscopy of 10-20 parietal cells in each animal. At 90 days immature parietal cells appeared in the center of the wound. These cells were characterized by large nuclei, small mitochondrial volume density, and few tubulo-vesicles. With further regeneration the parietal cells became ultrastructurally mature, but their total volume in the mucosa remained subnormal. Also the epithelial cell volume density was lower than normal after 260 days of healing.
More Related Videos
07:05Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Published on: May 12, 2019
04:18Enhanced Spatial Mapping of Mouse Gastric Muscle Layers Using a Modified Swiss Roll Technique
Published on: November 25, 2025
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Gastritis II: Pathophysiology
Peptic Ulcer Disease II: Pathophysiology