[Glucose tolerance on long-term treatment with a progestogen (etynodiol diacetate) (author's transl)]

Continuous long-term treatments with progestogens are able to bring about an hyperinsulinic reaction, which up till now has been considered to be due to a peripheral anti-insulin effect. Isolating the levels of immuno-reactive plasma insulin and of human C-peptide at the same time when loads of glucose and of tolbutamide are given after one another would seem to demonstrate that there is a primitive beta-islet of Langerhans origin for this hyperinsulinaemia. These results show that it is safe to prescribe etynodiol diacetate to "normal" patients as well as to "diabetic" patients.