Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrachromosomal gene conversion in yeast

H L Klein, T D Petes

    Nature
    |January 15, 1981
    PubMed
    Summary

    Researchers discovered a gene conversion mechanism in Saccharomyces cerevisiae. This process transfers genetic information between gene copies on the same chromosome, potentially maintaining gene family sequence uniformity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Unequal sister-strand recombination within yeast ribosomal DNA does not require the RAD 52 gene product.

    Current genetics·2013
    Same author

    Spontaneous chromosome loss in Saccharomyces cerevisiae is suppressed by DNA damage checkpoint functions.

    Genetics·2002
    Same author

    Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.

    Molecular and cellular biology·2001
    Same author

    Meiotic recombination involving heterozygous large insertions in Saccharomyces cerevisiae: formation and repair of large, unpaired DNA loops.

    Genetics·2001
    Same author

    High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability.

    Molecular and cellular biology·2001
    Same author

    The Saccharomyces cerevisiae suppressor of choline sensitivity (SCS2) gene is a multicopy Suppressor of mec1 telomeric silencing defects.

    Genetics·2001

    Area of Science:

    • Molecular Biology
    • Genetics
    • Yeast Research

    Background:

    • Eukaryotic genes often exist in families with repeated sequences.
    • Maintaining sequence homogeneity in these families is crucial for proper gene function.
    • Mechanisms for ensuring sequence integrity across repeated genes are not fully understood.

    Purpose of the Study:

    • To investigate the existence and nature of gene information transfer within a single chromosome.
    • To elucidate the mechanism of non-reciprocal gene transfer in Saccharomyces cerevisiae.
    • To determine the potential role of this mechanism in maintaining sequence homogeneity of eukaryotic gene families.

    Main Methods:

    • Utilizing the yeast Saccharomyces cerevisiae as a model organism.
    • Employing genetic analysis to track information transfer between gene copies.
    • Investigating intrachromosomal gene conversion events.

    Main Results:

    • Demonstrated a mechanism for non-reciprocal transfer of genetic information between gene copies on the same chromosome in yeast.
    • Identified intrachromosomal gene conversion as the process responsible for this information transfer.
    • Provided evidence for the role of this mechanism in maintaining sequence homogeneity.

    Conclusions:

    • Intrachromosomal gene conversion in Saccharomyces cerevisiae facilitates the transfer of genetic information between repeated genes.
    • This mechanism is likely essential for preserving sequence identity within eukaryotic gene families.
    • Understanding this process offers insights into genome stability and evolution.

    Related Experiment Videos