Related Experiment Videos
[Immunological monitoring after renal transplantation from living donors]
Monitoring of immune responses were done in kidney recipients from living donors using the following assays: CH-50, alternative pathway of complement activation, circulating Ag-Ab complexes, cytotoxic antibodies. All patients had survived 3 to 5 years from transplant. While some alternations (fall of CH-50, cytotoxic antibodies, circulating Ag-Ab complexes) occurred after the episodes of chronic rejection in 2 patients, despite a well functioning allograft, the inhibition of alternative pathway of complement activation demonstrated a coincidental capability to predict rejection episodes. The blocking mechanism of the alternative pathway of complement activation during rejection is not fully understood. The enhancing role of B-lymphocyte antibodies and the function of circulating immunecomplexes were also discussed.
Monitoring of immune responses were done in kidney recipients from living donors using the following assays: CH-50, alternative pathway of complement activation, circulating Ag-Ab complexes, cytotoxic antibodies. All patients had survived 3 to 5 years from transplant. While some alternations (fall of CH-50, cytotoxic antibodies, circulating Ag-Ab complexes) occurred after the episodes of chronic rejection in 2 patients, despite a well functioning allograft, the inhibition of alternative pathway of complement activation demonstrated a coincidental capability to predict rejection episodes. The blocking mechanism of the alternative pathway of complement activation during rejection is not fully understood. The enhancing role of B-lymphocyte antibodies and the function of circulating immunecomplexes were also discussed.