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Nutritional aspects of urolithiasis

W M Ringsdorf, E Cheraskin

    Southern Medical Journal
    |January 1, 1981
    PubMed
    Summary

    While vitamin C is linked to urinary tract stones, controlled studies are lacking. Only individuals with altered metabolism converting vitamin C to oxalate face high risk.

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    The vitamin C connection.

    Diabetic medicine : a journal of the British Diabetic Association·1995

    Area of Science:

    • Urology
    • Nutritional Science
    • Metabolic Disorders

    Background:

    • Concerns exist regarding vitamin C intake and urinary tract stone formation (lithiasis), specifically oxalate and uric acid stones.
    • Existing evidence lacks controlled clinical studies to substantiate a direct causal link between vitamin C and lithiasis.

    Purpose of the Study:

    • To evaluate the relationship between vitamin C consumption and the incidence of urinary tract lithiasis.
    • To highlight the importance of other nutritional factors in the development of kidney stones.

    Main Methods:

    • The study critically reviewed existing literature and clinical observations.
    • It focused on identifying specific metabolic conditions predisposing individuals to stone formation from vitamin C intake.

    Main Results:

    • No controlled clinical studies demonstrate that vitamin C consumption causes oxalate or uric acid lithiasis.
    • A rare metabolic subgroup, converting vitamin C to oxalic acid, represents the primary high-risk category for stone formation.

    Conclusions:

    • Vitamin C is unlikely to be the sole cause of kidney stones in the general population.
    • Investigating other nutritional variables in individuals with altered metabolism may help mitigate vitamin C-related lithiasis risks.

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