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Immunity and skin cancer

E B Smith, M M Brysk

Southern Medical Journal

|January 1, 1981

Summary

Skin cancer development may be linked to declining immune function and ultraviolet light exposure. Age and other factors like poor nutrition further weaken the immune system, increasing cancer risk.

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Area of Science:

Immunology
Dermatology
Oncology

Background:

Immunologic surveillance is theorized to prevent skin malignancies.
Immune responses naturally decline with age.
Factors like bereavement, poor nutrition, and UV exposure can further impair immunity.

Purpose of the Study:

To explore the relationship between diminished immune function and skin cancer development.
To investigate the combined impact of aging, environmental factors, and UV radiation on skin cancer risk.

Main Methods:

Review of human and animal studies on immunologic surveillance and skin malignancies.
Analysis of factors contributing to immune system decline.

Main Results:

Observations support the role of immunologic surveillance in limiting skin cancer.
Immune function progressively diminishes with age.
Bereavement, poor nutrition, and UV exposure exacerbate immune decline.

Conclusions:

Decreased immune function, particularly with age, is a significant factor in skin cancer.
The carcinogenic effects of UV light, combined with weakened immunity, are crucial in skin cancer etiology.

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