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Related Experiment Videos

Long-term drift and continued efficacy after multiyear timolol therapy

R F Steinert, J V Thomas, W P Boger

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |January 1, 1981
    PubMed
    Summary
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    Timolol maleate effectively lowers intraocular pressure (IOP) in glaucoma patients. However, discontinuing timolol causes a significant IOP increase, requiring at least two weeks for its effects to fully dissipate.

    Area of Science:

    • Ophthalmology
    • Clinical Pharmacology

    Background:

    • Primary open-angle glaucoma is characterized by elevated intraocular pressure (IOP).
    • Timolol maleate is a commonly prescribed medication for managing glaucoma.

    Purpose of the Study:

    • To review the clinical course of patients treated with timolol maleate.
    • To reevaluate the effect of timolol maleate on intraocular pressure in glaucoma patients.

    Main Methods:

    • Retrospective review of 41 patients on experimental protocols with timolol maleate.
    • Focused reevaluation of 17 primary open-angle glaucoma patients treated with timolol alone or in combination therapy for up to 35 months.

    Main Results:

    • Timolol withdrawal resulted in an average intraocular pressure increase of 5 mm Hg.

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  • Eight patients on timolol alone demonstrated a significant long-term "drift" or upward rise in IOP (3 mm Hg).
  • The IOP rise post-withdrawal was comparable to the initial IOP reduction upon treatment initiation.

    • Conclusions:

    • Timolol maleate withdrawal leads to a substantial and rapid increase in intraocular pressure.
    • A minimum of two weeks is necessary for complete timolol maleate washout.
    • Re-treatment with timolol maleate can restore IOP to pre-withdrawal levels within one week.