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[Method for testing niacin bound activities in man]

S Sestini, M L Ceccuzzi, C Ricci

    Bollettino Della Societa Italiana Di Biologia Sperimentale
    |June 30, 1980
    PubMed
    Summary
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    Testing enzyme activity in red blood cells is key to understanding niacin availability. Nicotinate-phosphoribosyltransferase activity in erythrocytes accurately reflects niacin status in humans.

    Area of Science:

    • Biochemistry
    • Human Physiology
    • Nutritional Science

    Context:

    • Niacin (vitamin B3) is essential for human health.
    • Assessing niacin status is crucial for preventing deficiencies.
    • Enzyme activity in erythrocytes offers a potential biomarker.

    Purpose:

    • To evaluate the utility of two key enzymes in assessing human niacin availability.
    • To determine which enzyme, nicotinate-phosphoribosyltransferase or nicotinamide-phosphoribosyltransferase, is a better indicator of niacin status.

    Summary:

    • Two enzymes, nicotinate-phosphoribosyltransferase and nicotinamide-phosphoribosyltransferase, were assayed in human erythrocytes.
    • Nicotinamide-phosphoribosyltransferase showed low activity, making it unsuitable for niacin availability assessment.

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  • Nicotinate-phosphoribosyltransferase activity proved to be a reliable indicator of niacin availability.

    • Impact:

    • This research provides a more suitable method for evaluating niacin status in humans.
    • The findings can aid in the diagnosis and management of niacin-related metabolic disorders.
    • Establishes nicotinate-phosphoribosyltransferase as a valuable biomarker for niacin nutritional assessment.