Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does reduced colloid oncotic pressure increase pulmonary dysfunction in sepsis?

J P Kohler, C L Rice, C K Zarins

    Critical Care Medicine
    |February 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of blood flow occlusion on corticospinal excitability during sustained low-intensity isometric elbow flexion.

    Journal of neurophysiology·2020
    Same author

    Short interspike intervals and double discharges of anconeus motor unit action potentials for the production of dynamic elbow extensions.

    Journal of neurophysiology·2014
    Same author

    Motor unit properties from three synergistic muscles during ramp isometric elbow extensions.

    Experimental brain research·2013
    Same author

    EVAR deployment in anatomically challenging necks outside the IFU.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2013
    Same author

    Reduced motor unit discharge rates of maximal velocity dynamic contractions in response to a submaximal dynamic fatigue protocol.

    Journal of applied physiology (Bethesda, Md. : 1985)·2012
    Same author

    Changes in motor unit recruitment thresholds of the human anconeus muscle during torque development preceding shortening elbow extensions.

    Journal of neurophysiology·2012

    Sepsis causes pulmonary dysfunction, but this effect is not linked to changes in colloid oncotic pressure (COP) or pulmonary artery wedge (PAW) pressure. Reduced COP alone did not cause pulmonary edema in septic baboons.

    Area of Science:

    • Physiology
    • Pathophysiology
    • Critical Care Medicine

    Background:

    • Starling's hypothesis explains fluid movement across capillaries based on oncotic pressure and permeability.
    • Decreased intracapillary colloid oncotic pressure (COP) or increased capillary permeability typically leads to increased interstitial fluid.
    • Sepsis is a common cause of clinical pulmonary dysfunction, prompting investigation into its relationship with COP and pulmonary artery wedge (PAW) pressure.

    Purpose of the Study:

    • To investigate whether a reduced COP-PAW gradient in the presence of sepsis increases pulmonary dysfunction.
    • To determine if sepsis-induced pulmonary dysfunction is dependent on colloid oncotic forces.

    Main Methods:

    • Twenty baboons were divided into four groups: control, sepsis (E. coli infusion), plasmapheresis alone, and plasmapheresis followed by sepsis.

    Related Experiment Videos

  • Pulmonary artery wedge (PAW) pressure was kept constant using Ringer's lactate infusion.
  • Arterial and mixed venous blood gases were analyzed to calculate the intrapulmonary shunt (QS/QT).
  • Statistical analysis included Tukey's HSD test and one-way analysis of variance.

    • Main Results:

    • Plasmapheresis significantly reduced COP by 68% in both plasmapheresis groups.
    • Sepsis increased the intrapulmonary shunt (QS/QT) in all septic animals.
    • Animals subjected to plasmapheresis followed by sepsis (group 4) did not show an increased QS/QT compared to controls, despite reduced COP.

    Conclusions:

    • Sepsis independently leads to pulmonary dysfunction.
    • The pulmonary dysfunction observed in sepsis appears to be independent of colloid oncotic forces.
    • Reduced COP alone, even in the context of sepsis, does not appear to cause pulmonary interstitial edema.